Integrated Clinical Research
BWH lung investigators have contributed to the development of more than 30 study populations for respiratory research, which include more than 100,000 subjects. These study populations have been used for genetic studies ranging from genome-wide association analysis to large-scale DNA sequencing. More recently, multiple types of –Omics assessments (e.g., transcriptomics, metabolomics, epigenetics, etc.) have been measured and analyzed using systems biology and network science approaches. These Precision Medicine efforts are already translating research advances to improved clinical care, such as the development of the BWH Pulmonary Genetics Clinic.
Translational Research in Lung Cancer
BWH lung scientists have led the investigating of lung cancer detection, staging and treatment including new intra-operative imaging approaches to localize and guide surgical removal of lung cancers and to map the pathways whereby tumor cells escape to nearby lymph nodes, improve quality of life and reduce morbidity before and after surgery, and studies of new targeted cancer treatments.