5th Annual Lung Research Center Symposium
1:00 - 3:30 PM ET | Wednesday, February 16th, 2022
Virtual

There is a separate registration for the virtual lunch (see agenda below for details).

The Brigham Research Institute’s (BRI) Lung Research Center cordially invites you to participate in its 5th annual symposium. This virtual event will feature a keynote address by Dr. Marlene Rabinovitch, the Dwight and Vera Dunlevie Professor of Pediatric Cardiology at Stanford University and will be followed by a poster session open to all BWH researchers working in the field of lung biology. The goal of the symposium is to bring together pulmonary-related researchers and clinicians at BWH, highlight the exciting research activities of the lung community and encourage cross-collaborative research efforts.

AGENDA

Virtual Lunch with Dr. Marlene Rabinovitch, Keynote Speaker

12:00 – 1:00 PM ET
Separate Registration is required for the lunch.
This is restricted to BWH trainees and junior faculty (Instructor and Assistant Professor). You must submit your interest to attend by noon ET on Monday, February 14th by clicking here.

 

Keynote Address

1:00 – 2:00 PM ET

Converging Genetic and Inflammatory Pathways Suggest New Therapies for Pulmonary Arterial Hypertension
Marlene Rabinovitch, MD
Dwight and Vera Dunlevie Professor of Pediatrics, Cardiology
Director, Basic Science and Engineering (BASE) Initiative,
Betty Irene Moore Children’s Heart Center
Stanford University

 

Poster Session

2:00 – 3:00 PM ET

 

Panel Discussion

3:00 – 3:30 PM ET

Hear from our distinguished panelists on the topics of building and maintaining research programs, establishing meaningful collaborations, and the transformative research areas of the future.

 

MODERATORS

Nora Barrett, MD

Director of Research Training, Allergy and Clinical Immunology Division, Brigham and Women’s Hospital
Assistant Professor of Medicine, Harvard Medical School

Yohannes Tesfaigzi, PhD

Director of Cigarette Smoke Exposure Laboratory, Brigham and Women’s Hospital
AstraZeneca Professor of Medicine in the Field of Respiratory and Inflammatory Diseases, Harvard Medical School

 

PANELISTS

Marlene Rabinovitch, MD

Dwight and Vera Dunlevie Professor of Pediatrics, Cardiology
Director, Basic Science and Engineering (BASE) Initiative,
Betty Irene Moore Children’s Heart Center, Stanford University

Joshua Boyce, MD

Chief, Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital
Albert L. Sheffer Professor of Medicine in the Field of Allergic Disease, Harvard Medical School

Raphael Bueno, MD

Chief, Division of Thoracic and Cardiac Surgery
Fredric G Levin Distinguished Chair in Thoracic Surgery and Lung Cancer Research

Bruce Levy, MD

Chief, Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital
Parker B. Francis Professor, Harvard Medical School

Edwin Silverman, MD, PhD

Chief, Channing Division of Network Medicine, Brigham and Women’s Hospital
Physician, Brigham and Women’s Hospital
Professor of Medicine, Harvard Medical School

About the Keynote

Marlene Rabinovitch, MD
Dwight and Vera Dunlevie Professor of Pediatrics, Cardiology
Director, Basic Science and Engineering (BASE) Initiative,
Betty Irene Moore Children’s Heart Center
Stanford University

Poster Presenters

2:00 – 3:00 PM ET

In order of presentation and theme/breakout room

Theme: Basic Mechanisms in Lung Pathobiology
Abbreviated Breakout Room Name: Basic Mech in Lung Pathobiology

Moderated by: Nora Barrett, MD

Nicola Alesi, MD, PhD, Instructor, Medicine, Pulmonary and Critical Care Division: Role of the Lysosome in the Pathogenesis of lymphangioleiomyomatosis (LAM)

Damir Khabibullin, MS, Research Associate/Lab Manager , Medicine, Pulmonary and Critical Care Division: Roles of Tfe3 and Tfeb in Mediating Mesenchymal Cell Abnormality Caused by FLCN Deficiency in Birt-Hogg-Dube Syndrome

Robin Lu, Student, Medicine, Channing Division of Network Medicine: Comparison of Lung and Blood Transcriptomics Reveals Shared Emphysema-Associated Pathways and Alternatively Spliced Genes

Jun Nagai, Instructor, Medicine, Allergy and Clinical Immunology: Alveolar Macrophage P2Y6 Receptor Signaling Regulates NFATc2 Activation to Potentiate Innate Anti-allergic Immune Responses

Xin Wang, PhD, Research Fellow, Medicine, Allergy and Clinical Immunology: Basal Cell Adhesion Molecule Marks An Airway Stem Cell Maintained Through IRS Signaling

Bradley Wertheim, MD, Instructor, Medicine, Pulmonary and Critical Care Division: C-terminal Src Kinase Inhibits Endothelial Fibrosis and is Upregulated in Early-Stage Experimental Pulmonary Arterial Hypertension

Theme: Clinical Imaging and Diagnostics in Lung and Pulmonary Vascular Diseases
Abbreviated Breakout Room Name: ClinicalImaging&Diag in Lung&PVD

Moderated by: Mark Perrella, MD

Laura Chiel, MD, Research Fellow, Medicine, Pulmonary and Critical Care Division: A Machine Learning Derived Smartphone-Based Cough Detection Algorithm

Alejandro Diaz, MD, MPH, Assistant Professor, Medicine, Pulmonary and Critical Care Division: Artificial Intelligence-based CT Airway to Artery Ratios and Exacerbations in Smokers: A Longitudinal Study of COPDGene

Gregory McDermott, MD, Research Fellow, Medicine, (Allergy) Rheumatology: Associations of the MUC5B Promoter Variant with Timing of Interstitial Lung Disease and Rheumatoid Arthritis Onset

Matthew Moll, MD, MPH, Instructor, Medicine, Channing Division of Network Medicine: Integration of a MUC5B Promoter Variant and a Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities

Farhad Rikhtegar Nezami, PhD, Lead investigator, Surgery, Thoracic Surgery: Risk of Cardiac Ischemia in Respiratory Failure Patients Using Upper Body Venoarterial Extracorporeal Membrane Oxygenation: A Computational Study

Andrew Tsao, BS, Research Assistant, Medicine, Pulmonary and Critical Care Division: Fractal Dimension Estimation Using Box-Counting to Quantify CT-Based Pulmonary Vascular Tree Simplification

Theme: Lung Cancer Phenotyping and Therapy
Abbreviated Breakout Room Name: LungCancerPhenotyping&Therapy

Moderated by: Assunta De Rienzo, PhD

Elio Adib, MD, Research Fellow, Medicine, Pulmonary and Critical Care Division: Variation in Targetable Genomic Alterations in Non-Small Cell Lung Cancer by Genetic Ancestry, Sex, Smoking History and Histology

Juuso Paajanen, MD, PhD, Research Fellow, Surgery, Thoracic Surgery: The Use of Single-nucleus RNA-sequencing in Malignant Pleural Mesothelioma: A Pilot Study

Mehrdad Rakaee, PhD, Research fellow, Medicine, Pulmonary and Critical Care Medicine: Digital Quantification of Lymphocytic Infiltration on Routine H&E Images Predicts Efficacy of Immunotherapy in NSCLC

Ahmed Sadek, MD, Research Fellow, Surgery, Thoracic Surgery: Large Scale Single Cell Sequencing of Lung Libraries for Tumor Comparison

Yan Tang, PhD, Instructor, Medicine, Pulmonary and Critical Care Medicine: Single Cell Analysis of Tuberous Sclerosis Complex (TSC) Reveals a Stem-like Tumor State Linked to Immune Suppression

Sayeda Yasmin-Karim, MBBS, MS, PhD, Instructor, Radiation Oncology, Medical Physics and Biophysics Division: Aerosol Delivery of Immunotherapy and Hesperetin Nanoparticles in Murine Lung Cancer Model

Theme: Molecular Profiling in Asthma, COPD, and Vaping
Abbreviated Breakout Room Name: Mol Profiling Asthma COPD Vaping

Moderated by: Craig Hersh, MD

Yih-Chieh Chen, MD, Research Fellow, Medicine, Allergy and Clinical Immunology: The Association of 17q21 Variants and Gut Microbiome in Childhood Asthma

Andrew Gregory, BS, Medical Student, Medicine, Channing Division of Network Medicine: Electronic Nicotine Delivery Systems Use is Associated with Multi-omic Biomarkers and Prospective Cardiopulmonary Health Outcomes

Jarrett Morrow, PhD, Instructor, Medicine, Channing Division of Network Medicine: Lung B Cell Gene Expression Signature of Emphysema in Peripheral Blood

Rinku Sharma, PhD, Research fellow, Medicine, Channing Division of Network Medicine: Circulating MicroRNA: A Potential Biomarker for ICS Treatment Response.

Rahul Suryadevara, Student, Medicine, Channing Division of Network Medicine: Blood Transcriptomics-Based Machine Learning Prediction of Emphysema in Smokers

Jeong Yun, MD, MPH, Instructor, Medicine, Channing Division of Network Medicine: Lung Tissue Gene Expression Profile of Eosinophilic Chronic Obstructive Pulmonary Disease

Yu-Hang Zhang, PhD, Research Fellow, Medicine, Channing Division of Network Medicine: Integrating Genetics, Transcriptomics, and Proteomics in Lung Tissue to Investigate COPD

Video Showcase

You can see the list of the showcase presenters below. 

Elio Adib, MD, Research Fellow, Medicine, Pulmonary and Critical Care Division, Elio Adib, MD*, Amin H. Nassar, MD, Sarah Abou Alaiwi, MD, Stefan Groha, PhD, Elie W. Akl, MD, Lynette M. Sholl, MD, Kesi Michael, BS, Mark M. Awad, MD, PhD, Pasi A. JÓ“nne, MD, PhD, Alexander Gusev, PhD, David J. Kwiatkowski, MD, PhD: Variation in Targetable Genomic Alterations in Non-Small Cell Lung Cancer by Genetic Ancestry, Sex, Smoking History and Histology

 

Nicola Alesi, MD, PhD, Instructor, Medicine, Pulmonary and Critical Care Division, Nicola Alesi*, Dean M Rosenthal, Damir Khabibullin, Michel Alchoueiry, Charbel Hobeika, Elizabeth P Henske: Role of the Lysosome in the Pathogenesis of lymphangioleiomyomatosis (LAM)

 

Yih-Chieh Chen, MD, Research Fellow, Medicine, Allergy and Clinical Immunology, Yih-Chieh S. Chen MD*, Robert S. Zeiger MD., PhD, George T. O’Connor, Leonard B. Bacharier, Nancy Laranjo BA, Jessica Lasky-Su DSc, MS, Yulu Chen, PhD, Augusto A. Litonjua MD, MPH, Scott T. Weiss MD, MS, Kathleen A. Lee-Sarwar1 MD, MS Funding Sources: Grant R01 HL091528 and UH3 OD023268 from National Health, Lung and Blood Institute (NHLBI; to Drs. Scott T. Weiss and Augusto A. Litonjua). Dr. Chen is supported by T-32 HL007427 and T-32 AI007306 from NHLBI.: The Association of 17q21 Variants and Gut Microbiome in Childhood Asthma

 

Laura Chiel, MD, Research Fellow, Medicine, Pulmonary and Critical Care Division, Laura Chiel*, Ebrahim Nemati, Suzanne Dahlberg, Dan McCaffrey, Bruce Levy, Benjamin Raby, Christopher Hardy Fanta: A Machine Learning Derived Smartphone-Based Cough Detection Algorithm

 

Tahereh Mina Derakhshan, Research Fellow, Medicine, Allergy and Clinical Immunology, T. Derakhshan*, E. Hollers, K. Buchheit, T. Laidlaw, J.A. Boyce, D.F. Dwyer: TGF-β Signaling is Central in Development of Human Intraepithelial Mast Cell Phenotype

 

Alejandro Diaz, MD, MPH, Assistant Professor, Medicine, Pulmonary and Critical Care Division, Alejandro A. Diaz, * Pietro Nardelli, Wei Wang, Ruben San José Estépar, Wojciech R. Dolliver, Andrew Tsao, Jose L. Orejas, Edwin K. Silverman, Raul San José Estépar: Artificial Intelligence-based CT Airway to Artery Ratios and Exacerbations in Smokers: A Longitudinal Study of COPDGene

 

Andrew Gregory, BS, Medical Student, Medicine, Channing Division of Network Medicine, Andrew Gregory*, Zhonghui Xu, Katherine Pratte, Seth Berman, Noah Lichtblau, Robin Lu, Rahul Suryadevara, Robert Chase, Jeong H. Yun, Aabida Saferali, Craig P. Hersh, Edwin K. Silverman, Russell P. Bowler, Adel Boueiz, Peter J. Castaldi: Electronic Nicotine Delivery Systems Use is Associated with Multi-omic Biomarkers and Prospective Cardiopulmonary Health Outcomes

 

Damir Khabibullin, MS, Research Associate/Lab Manager , Medicine, Pulmonary and Critical Care Division, Damir Khabibullin*, Yongfeng Luo, Hui Chen, Wei Shi and Lisa Henske: Roles of Tfe3 and Tfeb in Mediating Mesenchymal Cell Abnormality Caused by FLCN Deficiency in Birt-Hogg-Dube Syndrome

 

Wonji Kim, Research Fellow, Medicine, Channing Division of Network Medicine, Wonji Kim*, Xiaowei Hu, Bing Yu, Laura J. Rasmussen-Torvik, Sina A. Gharib, Brian Cade, Josée Dupuis, Robert Kaplan, Solomon Musani, Jennifer Brody, Stephanie J. London, Ravi Kalhan, Susan Redline, Bruce M. Psaty, George T. O’Connor, Adolfo Correa, Edwin K. Silverman, Dandi Qiao, Ani Manichaikul, Michael H. Cho and the TOPMed Investigators: Whole Genome Sequence Analysis of Pulmonary Function and COPD for 44,403 Multi-ethnic participants from the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

 

Robin Lu, Student, Medicine, Channing Division of Network Medicine, Robin Lu*, Rahul Suryadevara, Zhonghui Xu, Dhawal Jain, Andrew Gregory, Brian D. Hobbs, Noah Lichtblau, Robert Chase, Jeong H. Yun, Aabida Saferali, Ed K. Silverman, Craig P. Hersh, Peter Castaldi, Adel El Boueiz: Comparison of Lung and Blood Transcriptomics Reveals Shared Emphysema-Associated Pathways and Alternatively Spliced Genes

 

Gregory McDermott, MD, Research Fellow, Medicine, (Allergy) Rheumatology, Gregory McDermott*, Ritu Gill, Staci Gagne, Suzanne Byrne, Weixing Huang, Jing Cui, Lauren Prisco, Alessandra Zaccardelli, Lily Martin, Vanessa L. Kronzer, Matthew Moll, Michael H. Cho, Nancy Shadick, Paul Dellaripa, Tracy Doyle, Jeffrey A. Sparks: Associations of the MUC5B Promoter Variant with Timing of Interstitial Lung Disease and Rheumatoid Arthritis Onset

 

Matthew Moll, MD, MPH, Instructor, Medicine, Channing Division of Network Medicine, Matthew Moll1*, Sung Gook Chun, Richard J. Allen, Auyon J Ghosh1, John Ziniti, Rachel K. Putman, Hiroto Hatabu, Julian Hecker, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Brian D. Hobbs1, Edwin K. Silverman1, Benjamin A. Raby, Louise V. Wain, Gary M. Hunninghake, Michael H. Cho: Integration of a MUC5B Promoter Variant and a Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities

 

Jarrett Morrow, PhD, Instructor, Medicine, Channing Division of Network Medicine, Jarrett D. Morrow *, Peter J. Castaldi, Adel Boueiz, Robert P. Chase, Jeong H. Yun, Edwin K. Silverman, Craig P. Hersh: Lung B Cell Gene Expression Signature of Emphysema in Peripheral Blood

 

Jun Nagai, Instructor, Medicine, Allergy and Clinical Immunology, Jun Nagai*, Junrui Lin, Joshua A. Boyce: Alveolar Macrophage P2Y6 Receptor Signaling Regulates NFATc2 Activation to Potentiate Innate Anti-allergic Immune Responses

 

Juuso Paajanen, MD, PhD, Research Fellow, Surgery, Thoracic Surgery, Juuso Paajanen*, Matthew Brian Couger, Ahmed Sadek, David T. Severson, Benjamin Wadowski, Corinne E. Gustafson, Eugene Kim, Sam Weinhouse, Kristina Sidopoulos, William G. Richards, Assunta De Rienzo, and Raphael Bueno: The Use of Single-nucleus RNA-sequencing in Malignant Pleural Mesothelioma: A Pilot Study

 

Mehrdad Rakaee, PhD, Research Fellow, Medicine, Pulmonary and Critical Care Medicine, Mehrdad Rakaee*, Elio Adib, Biagio Ricciuti, Lynette M Sholl, Joao V Alessi, Juha P. Väyrynen, Elin Richardsen, Sigve Andersen, Lill-Tove Rasmussen Busund, Tom Donnem, Mark M. Awad, David J. Kwiatkowski: Digital Quantification of Lymphocytic Infiltration on Routine H&E Images Predicts Efficacy of Immunotherapy in NSCLC

 

Farhad Rikhtegar Nezami, PhD, Lead investigator, Surgery, Thoracic Surgery, Hamed Moradi, Elazer R. Edelman, Steven P. Keller, Farhad R. Nezami*: Risk of Cardiac Ischemia in Respiratory Failure Patients Using Upper Body Venoarterial Extracorporeal Membrane Oxygenation: A Computational Study

 

Ahmed Sadek, MD, Research Fellow, Surgery, Thoracic Surgery, Ahmed Sadek*, Matthew Brian Couger, Vivian Wang, Juuso Paajanen, David T. Severson, Molly Likes, Mary Dao, Simona Innocenti, Sarah Lobo, Corinne Gustafson, William G. Richards, Assunta De Rienzo, and Raphael Bueno: Large Scale Single Cell Sequencing of Lung Libraries for Tumor Comparison

 

David Severson, DPhil, Medical Student, Surgery, Thoracic Surgery, David T Severson*†, Samuel Freyaldenhoven†, Benjamin Wadowski†, Travis Hughes, Yin P Hung, Roderick V Jenson, William G Richards, Corinne Gustafson, Julianne S Barlow, Matthew B Cougar, Jamie Anderson, Jason Meyerovitz, Vivian Wang, Mary N. Dao, Alex K. Shalek, Assunta De Rienzo, Raphael Bueno: Multi-site Profiling of Malignant Pleural Mesothelioma Using Single-cell RNA-seq Reveals Tumor-specific Histopathologic Heterogeneity

 

Rinku Sharma, PhD, Research Fellow, Medicine, Channing Division of Network Medicine, Rinku Sharma1*, Anshul Tiwari1, Alvin T. Kho2, Juan C Celedón3, Scott T. Weiss1, Kelan G. Tantisira4, and Michael J. McGeachie 1: Circulating MicroRNA: A Potential Biomarker for ICS Treatment Response

 

Rahul Suryadevara, Student, Medicine, Channing Division of Network Medicine, Rahul Suryadevara*, Robin Lu, Zhonghui Xu, Andrew Gregory, Aria Masoomi, Sharon M. Lutz, Seth Berman, Jeong H. Yun, Aabida Saferali, Craig P. Hersh, Edwin K. Silverman, Jennifer Dy, Peter J. Castaldi, Adel Boueiz: Blood Transcriptomics-Based Machine Learning Prediction of Emphysema in Smokers

 

Yan Tang, PhD, Instructor, Medicine, Pulmonary and Critical Care Medicine, Yan Tang*, David J. Kwiatkowski, Elizabeth P. Henske: Single Cell Analysis of Tuberous Sclerosis Complex (TSC) Reveals a Stem-like Tumor State Linked to Immune Suppression

 

Andrew Tsao, BS, Research Assistant, Medicine, Pulmonary and Critical Care Division, Andrew Tsao B.S.*, Pietro Nardelli Ph.D., Aaron B. Waxman M.D. Ph.D., Ruben San José Estépar, George Washko M.D. M.S., Raúl San José Estépar Ph.D., Farbod N. Rahaghi M.D. Ph.D.: Fractal Dimension Estimation Using Box-Counting to Quantify CT-Based Pulmonary Vascular Tree Simplification

 

Xin Wang, PhD, Research Fellow, Medicine, Allergy and Clinical Immunology, Xin Wang*, Nils Hallen, Sachin Samuchiwal, Minkyu Lee1, Katie Bucheit1, Neil Bhattacharyya, Soumya Raychaudhuri, Dan Dwyer, Tanya M. Laidlaw, Joshua A. Boyce, Maria Gutierrez-Arcelus, and Nora A. Barrett: Basal Cell Adhesion Molecule Marks An Airway Stem Cell Maintained Through IRS Signaling

 

Bradley Wertheim, MD, Instructor, Medicine, Pulmonary and Critical Care Division, Bradley M. Wertheim*, Rui-sheng Wang, Ying-Yi Zhang, Andriy O. Samokhin, George A. Alba, Elena Arons, William M. Oldham, Bradley A. Maron: C-terminal Src Kinase Inhibits Endothelial Fibrosis and is Upregulated in Early-Stage Experimental Pulmonary Arterial Hypertension

 

Sayeda Yasmin-Karim, MBBS, MS, PhD, Instructor, Radiation Oncology, Medical Physics and Biophysics Division, Amanda Fam, Giraud Richards, Mike Makrigiorgos, Sayeda Yasmin-Karim*: Aerosol Delivery of Immunotherapy and Hesperetin Nanoparticles in Murine Lung Cancer Model

 

Jeong Yun, MD, MPH, Instructor, Medicine, Channing Division of Network Medicine, Jeong H. Yun*, Auyon Ghosh, Brian D. Hobbs, Aabida Saferali, Robert Chase, Zhongui Xu, Edwin K. Silverman, Peter J. Castaldi, Craig P. Hersh: Lung Tissue Gene Expression Profile of Eosinophilic Chronic Obstructive Pulmonary Disease

 

Yu-Hang Zhang, PhD, Research Fellow, Medicine, Channing Division of Network Medicine, Yu-Hang Zhang*, Michael H. Cho, Peter J. Castaldi, Craig P. Hersh, Mukul K. Midha, Michael R. Hoopmann, Robert L. Moritz, Edwin K. Silverman: Integrating Genetics, Transcriptomics, and Proteomics in Lung Tissue to Investigate COPD

 

David Ziehr, MD, Research Fellow, Medicine, Pulmonary and Critical Care Division, David R. Ziehr, MD*, Kevin J. Leahy, MS, Jack Varon, MD, Rebecca M. Baron, MD, Edy Kim, MD PhD, Rachel S. Knipe, MD, William M. Oldham, MD PhD: Lactate Transport Inhibition Therapeutically Reprograms Fibroblast Metabolism in Experimental Pulmonary Fibrosis

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