ROC Election

BASIC SCIENCE SENIOR FACULTY

raouf

Raouf A. Khalil, MD, PhD
Associate Professor

Statement

I would like to introduce myself as an MD PhD who is very interested in basic science research. As a Research Investigator and Associate Professor in the Division of Vascular Surgery, Department of Surgery since 2004, I am very excited about the possibility of serving as the Basic Science Senior Faculty representative on the BRI Research Oversight Committee (ROC).

As a research representative, I will advocate for the interests of both established and young investigators, paying particular attention to issues related to availability of research resources, finding new funding opportunities, promoting collaborations in Center and Program Project grants, updating core facilities, and helping to maintain research infrastructure such as elevators, cold rooms, dark rooms, and distilled water supply.

I have been a strong advocate for research throughout my career. I have been a member of the Harvard Medical Area Standing Committee on Animals (IACUC), and the Partners Institutional Review Board (IRB), and an active member on several NIH, American heart Association, and International Grant Review Committees. I have also participated in numerous BRI activities including BRI Research Management Task Force, BRIght Futures Planning Committee, and the monthly RC LIVE lunches.

I have had excellent medical and research training and experience. After graduating from Medical School at Cairo University in 1976, I received my Masters in Pharmacology from Assiut University in 1983, then completed my PhD in Vascular Pharmacology at the University of Miami, Florida in 1979. Following fellowship training in Vascular Physiology and Molecular Biology at Harvard Medical School in 1994, I joined the faculty at the University of Mississippi Medical Center. I then joined the faculty at Harvard Medical School and Brigham and Women’s Hospital, where I am currently Associate Professor of Surgery and a Principal Investigator at the Vascular Surgery Research Laboratories. I oversee NIH-funded research projects, and serve on the editorial boards of over 10 scientific journals and as a reviewer for over 140 journals. My laboratory’s research focuses on understanding the cellular mechanisms of vascular tone under physiological conditions and the changes in these mechanisms in coronary artery disease, essential hypertension, and hypertension in pregnancy and preeclampsia.

Thank you very much for considering my nomination for this important position.

Shah_Khalid_2015_EP, Khalid Shah, MS, PhD
Head, Molecular Neurotherapy and Imaging Laboratory
Director, Stem Cell Therapeutics and Imaging Program
Department of Radiology and Neurology
Massachusetts General Hospital
Principal Faculty, Harvard Stem Cell Institute,

Khalid Shah, MS, PhD
Associate Professor

Statement

As an Associate Professor in the Neurosurgery department since 2017, I am very excited about the possibility of serving as the Senior Faculty representative on the BRI Research Oversight Committee (ROC).

As your representative, I will advocate for the interests of young investigators, paying particular attention to issues such as obtaining constant Research funding and increasing their ability to interact with the personnel both in academia and industry.

I was the director of Stem Cell Imaging Program from 2005-2010 and the Director of Center for Stem Cell Therapeutics and Imaging from 2010-2016 at MGH. Currently, I am the Vice Chair of Research in Neurosurgery and also the Director of Excellence in Biomedical Sciences at BWH.

I received my MS and PhD from Wageningen University and Research Center in 2001 where I studied cell signaling during embryogenesis. I did my post-doctoral work with Dr. Weissleder and Dr. Breakefield at MGH and started my laboratory in 2006 at MGH.

 

The overall goal of my Center is to develop and test novel targeted therapies for cancer. My research program, like my training, has been multidisciplinary and is focused on developing imageable mouse tumor models and engineering different stem cell types (adult and induced pluripotent cells) with therapeutic and diagnostic proteins to study the effect of stem cell delivered therapeutics in the tumor microenvironment. We capitalize on my unique expertise in interdisciplinary research spanning stem cell and tumor cell biology, genetic engineering and molecular imaging as well as our proven abilities to synthesize new insights from disparate fields, to lead interdisciplinary teams into new territory.

jing

Jing Zhou, MD, PhD
Professor

Statement

I am Professor of Medicine in the Renal Division, Department of Medicine at BWH. I am also the founding director of Harvard Center for Polycystic Kidney Disease Research. I set up my lab in the BWH since 1993 so I have some experience in doing research at the BWH.

I am very excited about the possibility of serving as the next Senior Faculty representative on the BRI Research Oversight Committee (ROC). I have been running the basic research and education efforts (Research retreat, Research seminars, courses, symposiums) for fellows and faculty in the renal division and in the PKD Center for over a dozen years and have established and facilitated a number of collaborations within and between the Departments in BWH. I have mentored over one hundred post-docs, fellows, students, and junior faculty member in my lab and some more in the division. I am interested in promoting research at the BWH by facilitating networking within between the faculty members, voice the needs of both junior and senior investigators and searching for solutions to meet the needs.

I was recruited to the BWH as Assistant Professor of Medicine in 1993 after being a junior faculty member at Yale studying renal genetics and molecular biology. Prior to Yale, I did my Ph.D. studies in renal genetics and matrix biology in Finland where we made the first breakthrough in molecular cloning in renal genetics. I practiced emergency and general medicine full time in a major hospital in China for six years, which serves a major inspiration for my research. Currently, my laboratory utilizes multidisciplinary approaches including molecular cell biology and molecular genetics to study the epithelial cell biology and inherited kidney diseases with focus on the primary cilia and polycystic kidney disease.

CLINICAL RESEARCH JUNIOR FACULTY

gregory

Katherine Gregory, PhD
Assistant Professor

Statement

As an Assistant Professor of Pediatrics in the Department of Pediatric Newborn Medicine since 2014, I welcome the possibility of serving as the Clinical Research Junior Faculty representative on the BRI Research Oversight Committee (ROC). As your representative on the ROC, I will advocate for the interests of early stage clinical research investigators, with a strong focus on ensuring that there are strategies for success available to investigators across departments and disciplines at Brigham and Women’s Hospital.  I am also interested in serving on the ROC so that I may help foster access to research funding from alternative funding sources (i.e. donors, venture capital, industry sponsors, and foundations) during this time of constrained federal funding for clinical research.  I have been involved in multiple BRI activities including Discover Brigham and the Shark Tank event.

 

My clinical background is in newborn intensive care nursing and my research is focused on gut health, nutrition, and growth of preterm infants.  I received my BS from SUNY Binghamton, MS from the University of Pennsylvania, and PhD from Boston College.  I completed my Career Development Award (K23) under the mentorship of Drs. Allan Walker (MGH), Linda Van Marter (BWH), and Bruce Kristal (BWH). My lab is currently focused understanding the acquisition and establishment of the intestinal microbiome of preterm infants and how these patterns influence short and long-term health outcomes via immune and metabolic-mediated mechanisms.

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Piotr Zygmanski, PhD
Assistant Professor

Statement

As an Assistant Professor of Radiation Oncology at BWH / DFCI / HMS in the Division of Medical Physics & Biophysics I am very excited about the possibility of serving as the Clinical Research Junior Faculty representative on the BRI Research Oversight Committee (ROC).

As your representative, I will serve as an ardent advocate of young investigators, promoting their research by reaching out and communicating their suggestions and concerns to BRI, as well as by reviewing BRI processes and contributing to the development of BRI programs and activities.

I did my PhD research in proton radiotherapy at the Harvard Cyclotron Laboratory (HCL) and I received PhD in Physics from the UMASS at Amherst in 1998. I did my postdoctoral fellowship at MGH, where I also completed my clinical medical physics residency in 2001. I joined the Department of Radiation Oncology at BWH / DFCI in 2001 as a faculty level staff Physicist. I am a Diplomat of American Board of Radiology (ABR) with specialization in radiation oncology physics since 2005. I have served as senior mentor of more than 15 physics postdoctoral fellows in Radiation Oncology, many of which have gone on to obtain independent faculty level positions.

My current research focuses on nanoparticle radiotherapy (NRT) treatment of prostate cancer, development of imaging for nanoparticle agents, radiomics of head and neck cancers and  development of medical imaging devices.

CLINICAL RESEARCH SENIOR FACULTY

Elizabeth Klerman, MD

Elizabeth B. Klerman, MD, PhD
Associate Professor

Statement

I am very excited about the possibility as serving as a Clinical Research Senior Faculty representative on the BRI Research Oversight Committee (ROC). I am an Associate Professor in the Division of Sleep and Circadian Disorders within the Departments of Medicine and Neurology. As your representative, I will advocate for clinical research priorities, paying particular attention to issues related to patient focused clinical research in healthy and other populations. I currently conduct both outpatient and inpatient research using the BWH Center for Clinical Research facilities and resources. I have served on CCI committees as well as on the BWH Clinical Investigation Committee. I received my MD and PhD from Harvard University in 1990; my PhD is in Physiology. I did my first post-doc in Japan as a on a joint NSF-Japan Society for the Promotion of Science fellowship, then an internship, and returned to the BWH in 1991 as a post-doctoral fellow. My areas of research are (i) the application of circadian and sleep research principles to normal and pathophysiologic states and (ii) mathematical analysis and modeling of human circadian, sleep, and neurobehavioral mood and performance rhythms. I also do mentoring work with fellows and junior faculty in patient-oriented research supported by a NIH K24 award.

kubicki

Marek Kubicki, MD, PhD
Associate Professor

Statement

Marek Kubicki is Radiologist who holds an M.D. and Ph.D. from the Medical Academy of Lodz, Poland. He has his primary appointment with the Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, where he is an Associate Director of Psychiatry Neuroimaging Laboratory. His secondary appointments are with the Departments of Radiology at BWH, and the Department of Psychiatry at Massachusetts General Hospital, where he is a director of Center for Morphometric Analysis at Martinos’ Imaging Center. For the last 18 years Marek has been associated with BWH, and has been using neuroimaging as a tool to study neuropsychiatric diseases, including schizophrenia. He has been involved in studies that use Diffusion Tensor Imaging (DTI), Magnetization Transfer Imaging (MTI), fMRI, and other imaging methods, and he has been on the forefront of developing non-standard measures and methods that will help us to understand better the neurobiology of brain diseases. Throughout his career he has been awarded several prestigious awards, including an NIH Young Investigator Travel Award (2003), two consecutive NARSAD Young Investigator Awards (2001-2003 and 2003-2005), an NIMH R03 grant (2003-2005), a Brigham and Women’s Hospital Translational Neuroscience Project Grant, a Harvard Milton Award (2006-2008), and he has been site PI on an NIH U54 center grant (2006-2009). Currently, he is a PI of two R01 NIH grants, an R21 grant, and the K24 NIMH grant. He has authored or co-authored over a hundred original research publications in peer-reviewed journals, and several peer reviewed review articles, book chapters, invited opinion articles and letters to the editor. Marek is a member of the editorial boards of Schizophrenia Research, Psychiatry Research: Neuroimaging, and Brain Imaging and Behavior. He is a frequent reviewer for NIH, as well as a member of Brain Canada and Charles A. King Trust Postdoctoral Fellowship Program review committees. He is also a member of several local committees (MGH Steering Committee for Psychiatric Research, HMS Psychiatry Research Committee, Lurie Center for Autism Scientific Advisory Board). and a co-director of T32 Stuart T. Hauser Clinical Research Training Program in Biological and Social Psychiatry at Harvard Medical School.

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Danny Muehlschlegel, MD, MMMsc, FAHA
Associate Professor – Incumbent

Statement

I joined Brigham and Women’s Hospital in 2006 for a clinical fellowship in cardiac anesthesia followed by the 2-year Scholars in Clinical Science Program at Harvard Medical School. Since then, I have been a practicing cardiac anesthesiologist with a primary research focus on genetics of cardiovascular disease, examining the effects of ischemia on expression changes in human myocardium, for which I have an NIH-funded translational research laboratory.

 

Throughout my years at BWFH, I have benefited and greatly appreciated the support, guidance, and mentorship of the Brigham Research Institute (BRI). I frequently attend its LIVE lunch series, have profited from micro grants, attended scientific poster sessions, and taken part in yearlong mentorship and leadership courses. Overall, I believe that the BRI is a phenomenal initiative that supports many productive programs throughout BWFH. With my past experience as an active BRI participant and investigator, I feel I can contribute to its current programs while helping to adapt it to future challenges. Particularly in this era of low funding rates and “angst” on the part of junior and senior investigators alike, the BRI is an essential part of BWFH, helping to shape and advance its culture of research excellence.

POPULATION SCIENCE JUNIOR FACULTY

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Brenda B. Birmann, ScD
Assistant Professor

Statement

As an Associate Epidemiologist and Assistant Professor of Medicine in the Channing Division of Network Medicine, Department of Medicine, I relish the opportunity to serve as the Population Science Junior Faculty representative on the Brigham Research Institute Research Oversight Committee (BRI ROC).

In this role I will represent the needs and concerns of junior faculty in the unique niche of population science and strive to keep our community informed of opportunities that could enhance our success and professional advancement through improved access to funding, networking, mentorship and other resources, and of relevant policies and programs.  I will be tenacious in advocating for resources to support junior faculty retention and advancement and to convey junior faculty perspectives in policy-related discussions.  I will actively encourage population science junior faculty colleagues to avail of the open guest spots at BRI ROC monthly meetings, to strengthen the connections and communication between our community and the broader BRI.

Currently at the Channing I co-coordinate a Career Development Seminar Series tailored for trainees and junior faculty and serve as formal or informal mentor to several local and long-distance trainees and early career investigators. I have participated in the Faculty Mentoring Leadership Program, Women’s Leadership Program and many of the seminars and networking opportunities offered by the Center for Faculty Development & Diversity and the Office for Women’s Careers, as well as BRI Research Days, Women in Medicine and Science Symposia and BRI Principal Investigator Input and Ideas (PI3) meetings. Through these activities I have come to recognize and appreciate the commitment of the BRI leadership to understanding and nurturing the research careers of junior faculty, as well as the diversity, talent and creativity of my BRI colleagues.  I have also held leadership positions in large international research consortia. In 2012 I was honored to receive the Young Scientist Award from the Lymphoma Foundation of America in recognition of my vision and early accomplishments in lymphoma etiology research.

I received my ScD in Epidemiology at the Harvard T.H. Chan School of Public Health, where I trained with Dr. Nancy Mueller (also for post-doctoral training) in cancer epidemiology and virus-related cancers. In 2006 I joined the Channing as an Instructor in Medicine and worked with Dr. Graham Colditz to launch a new research program in the Harvard cohorts focused on the etiology of multiple myeloma (MM).

I am excited to serve on the BRI ROC as a liaison and advocate for the population science community and am confident that the scientific rigor, creativity, leadership and advocacy skills that I have demonstrated in developing my local research program, on behalf of my mentees and in large consortia will also equip me to be effective in this new role.

Liz Janiak headshot 001

Elizabeth Janiak, ScD
Instructor

Statement

As a current Instructor and former Postdoctoral Research Fellow in Obstetrics, Gynecology, and Reproductive Biology, I am very excited about the possibility of serving as the Population Science Junior Faculty representative on the BRI Research Oversight Committee (ROC). Population Science constitutes the connective glue of the research cycle: from question generation through epidemiological explorations to designing and evaluating systems-level scale up of resulting solutions. As the representative in this area I will raise the visibility of research focused on understanding and ameliorating health inequities with respect to race, gender, sexual orientation, socioeconomic position, and other social determinants of health. I am an interdisciplinary public health researcher with expertise in sociology, epidemiology, and health systems research.  I received my undergraduate degree in the Comparative Study of Religion summa cum laude from Harvard College and earned masters and doctoral degrees in Social and Behavioral Sciences from the Harvard T.H. Chan School of Public Health. My current research focuses on how policy, health systems, and provider-level factors affect the availability, timeliness, and quality of reproductive health care services in the United States. I use qualitative and quantitative methods including analyses of administrative data and survey research. Current projects include several to improve the integration of reproductive life planning, preconception care, and contraceptive access in primary and specialty care settings.

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