Sex Differences in Molecular Mechanisms of Depression: Transcriptional and Epigenetic Studies Speaker: Eric Nestler, M.D., Ph.D., Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic
Sex Differences in Molecular Mechanisms of Depression: Transcriptional and Epigenetic Studies
Speaker: Eric Nestler, M.D., Ph.D., Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic and Scientific Affairs at Icahn School of Medicine at Mount Sinai.
Moderator: Kate Burdick, Ph.D
Depression is a common, chronic, and debilitating syndrome, which involves dysregulation throughout the brain’s limbic circuitry. Using mouse models, we have identified stable changes in gene expression within this circuitry that control vulnerability to different forms of stress and to the induction of depression-related behavioral abnormalities. In parallel studies on postmortem human tissue, we have examined transcriptional mechanisms in homologous regions in the brains of depressed individuals. A major interest in these animal and human studies is to understand sex differences in stress responses, given the greater prevalence of depression in females. Our work establishes transcriptional and chromatin regulation as important mechanisms through which a history of stress can lead to depression in vulnerable individuals, often in a sex-specific manner. Our long-term goal is to use these insights to develop improved diagnostic tests and treatments for depression and related syndromes.
About the Speaker:
Dr. Nestler is the Nash Family Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai in New York, where he serves as Dean for Academic and Scientific Affairs and Director of the Friedman Brain Institute. Dr. Nestler is a member of National Academy of Medicine (1998) and a fellow of the American Academy of Arts and Sciences (2005). He is a past President of the American College and Neuropsychopharmacology (2011) and the society for Neuroscience (2017). He is a founder and scientific advisory board chair for PsychoGenics, a member of the Board of Directors of Berg Pharma, and the author of more than 600 publications and five books.
(Wednesday) 4:00 pm - 5:00 pm
BWH Program for Interdisciplinary Neurosciencepstoll@bwh.harvard.edu https://www.bwhneurosciences.org/